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Updated: Jun 7, 2025
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Arming oncolytic M1 virus with gasdermin E enhances antitumor efficacy in breast cancer
Xiao-Yu Chen1, Ying Liu2, Wen-Bo Zhu1
1Departments of Pharmacology, Sun Yat-sen University, No. 074, Zhongshan Second Road, Guangzhou 510080, China.
Abstract:
Pyroptosis, driven by the N-terminal domain of gasdermin proteins (GSDM), promotes antitumor immunity by attracting lymphocytes to the tumor microenvironment (TME). However, current pyroptosis-inducing therapies like drug injections and phototherapy are limited to localized treatments, making them unsuitable for widespread or microscopic metastatic lesions. This study engineered oncolytic M1 viruses (rM1-mGSDME_FL and rM1-mGSDME_NT) to selectively deliver GSDME to tumor cells. These modified viruses enhanced tumor cell death in breast cancer models, suppressed tumor growth, extended survival in mice, and boosted immune cell infiltration, demonstrating significant anticancer potential through pyroptosis induction.
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