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NETosis in pulmonary pleomorphic carcinoma
Hajime Oi1,2,3, Tetsuro Taki1, Takashi Kuroe1
1Department of Pathology and Clinical Laboratories, National Cancer Center Hospital East, Kashiwa, Japan.
Cancer Science
|November 18, 2024
Summary
High NETosis areas in pulmonary pleomorphic carcinoma correlate with increased systemic inflammation and poorer patient survival following surgical resection.
Area of Science:
- Oncology
- Immunology
- Pathology
Background:
- Pulmonary pleomorphic carcinoma (PC) is a rare non-small-cell lung cancer with poor prognosis.
- Tumor necrosis (TN) is a common feature in PC.
- NETosis, a neutrophil cell death process, is implicated in inflammatory conditions.
Purpose of the Study:
- To investigate the prognostic significance of NETosis in pulmonary pleomorphic carcinoma.
- To assess the correlation between NETosis area and systemic inflammation markers.
- To evaluate NETosis as a potential biomarker in PC.
Main Methods:
- Seventy-six patients with resected pulmonary PC were analyzed.
- Tumor necrosis regions were quantified.
- NETosis areas were measured using citrullinated histone H3 (citH3) and myeloperoxidase staining.
- Associations with overall survival and systemic inflammation markers were examined.
Main Results:
- Tumor necrosis was present in 92% of patients.
- High NETosis area was significantly associated with shorter overall survival (p=0.013).
- Elevated NETosis correlated with higher systemic inflammation markers (CRP, CRP/albumin ratio, neutrophil/lymphocyte ratio).
- These inflammatory markers decreased post-surgery.
Conclusions:
- High NETosis area is an independent poor prognostic factor in surgically resected pulmonary PC.
- NETosis is linked to increased systemic inflammation in PC patients.
- NETosis quantification may aid in predicting outcomes for pulmonary pleomorphic carcinoma.
