Related Experiment Video

Updated: Jun 7, 2025

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

14.2K

Efficacy of sulforaphane in skin cancer animal models: A systematic review

Md Masoom1, Mohd Ashif Khan1

  • 1Department of Translational and Clinical Research, School of Chemical and Life Sciences, Jamia Hamdard University, New Delhi, India.

Polimery W Medycynie
|November 18, 2024
PubMed

Insights

Sulforaphane (SFN) shows promise in preventing skin cancer by inhibiting tumor growth and spread in animal models. Further research is needed to determine optimal human dosages for this cruciferous vegetable compound.

Area of Science:

  • Oncology
  • Chemoprevention
  • Dermatology

Background:

  • Skin cancer, particularly melanoma, is a growing global health concern with projected increases by 2040.
  • Sulforaphane (SFN), a natural compound from cruciferous vegetables, exhibits potential anticancer properties.
  • Urgent need for effective preventive strategies against escalating skin cancer rates.

Approach:

  • Systematic review of English-language studies from 2000-2023.
  • Inclusion of 9 relevant studies evaluated using the SYRCLE risk of bias tool for animal research.
  • Data extraction and quality assessment following predefined criteria.

Key Points:

  • SFN demonstrated significant chemopreventive effects against skin cancer in animal models.
  • SFN inhibited carcinogen-induced skin tumorigenesis, reduced tumor onset, and slowed cancer cell proliferation.
  • SFN protected against UVB-induced skin carcinogenesis by modulating the activator protein 1 pathway.

Conclusions:

  • SFN is a promising chemopreventive agent for skin cancer based on animal studies.
  • Optimal human SFN dosage, duration, and administration require further investigation.
  • SFN may offer a complementary or alternative approach to current skin cancer prevention methods.
Keywords:
animal modelschemopreventionskin cancersulforaphane

More Related Videos

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

1.5K
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

8.7K

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.5K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.5K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.7K
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
328
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K