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Updated: May 4, 2026

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
Published on: December 10, 2012
Selective Inference for Change Point Detection by Recurrent Neural Network
Tomohiro Shiraishi1, Daiki Miwa2, Vo Nguyen Le Duy3
1Department of Mechanical Systems Engineering, Nagoya University, Nagoya, Japan, 464-8603 shiraishi.tomohiro.nagoyaml@gmail.com.
Abstract:
In this study, we investigate the quantification of the statistical reliability of detected change points (CPs) in time series using a recurrent neural network (RNN). Thanks to its flexibility, RNN holds the potential to effectively identify CPs in time series characterized by complex dynamics. However, there is an increased risk of erroneously detecting random noise fluctuations as CPs. The primary goal of this study is to rigorously control the risk of false detections by providing theoretically valid p-values to the CPs detected by RNN. To achieve this, we introduce a novel method based on the framework of selective inference (SI). SI enables valid inferences by conditioning on the event of hypothesis selection, thus mitigating bias from generating and testing hypotheses on the same data. In this study, we apply an SI framework to RNN-based CP detection, where characterizing the complex process of RNN selecting CPs is our main technical challenge. We demonstrate the validity and effectiveness of the proposed method through artificial and real data experiments.

