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Related Experiment Video

Updated: Jun 7, 2025

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
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Evaluation of a Tailored Patient Navigation Program for Improving Multitarget Stool DNA Test Adherence.

Edward Cytryn1, Zachary Stauber1, Kayla Jaeckel2

  • 1Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Journal of General Internal Medicine
|November 18, 2024
PubMed
Summary

Tailored patient navigation (TPN) significantly improved colorectal cancer screening with multitarget stool DNA (mt-sDNA) tests. TPN increased test completion rates and reduced unusable samples, enhancing screening uptake.

Keywords:
cancer screeningcolon cancer screeningcolorectal cancercolorectal cancer screeningmultitarget stool DNAnoninvasive cancer screeningpatient navigationquality improvementstool DNAtailored patient navigation

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Area of Science:

  • Oncology
  • Preventive Medicine
  • Health Services Research

Background:

  • Multitarget stool DNA (mt-sDNA) tests are a noninvasive option for colorectal cancer screening.
  • Test adherence remains a challenge, potentially limiting the impact of mt-sDNA screening.
  • Tailored patient navigation (TPN) has shown success in improving adherence for other cancer screening methods.

Purpose of the Study:

  • To evaluate the effectiveness of TPN in improving mt-sDNA test completion rates.
  • To assess whether TPN can reduce the rate of samples that could not be processed (SCNBP).

Main Methods:

  • A prospective study was conducted in a large, urban, academic primary care clinic serving a medically vulnerable population.
  • Patients receiving mt-sDNA orders in 2022 (pre-intervention) and 2023 (intervention) were included.
  • During the 12-month intervention period, a patient navigator provided TPN to support test completion.

Main Results:

  • TPN was associated with a significant increase in 90-day mt-sDNA completion rates (51% vs. 39%).
  • TPN also led to a significant reduction in SCNBP results (4% vs. 5%).
  • These improvements were observed despite existing manufacturer navigation services.

Conclusions:

  • Tailored patient navigation is an effective strategy for enhancing colorectal cancer screening uptake via mt-sDNA testing.
  • TPN improves both test completion and sample quality, making it a valuable tool in preventive oncology.
  • The findings suggest TPN should be considered for mt-sDNA screening programs, particularly in vulnerable populations.