Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

46
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
46
Esophageal Varices-I: Introduction01:24

Esophageal Varices-I: Introduction

74
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
74
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

143
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
143
Disorders of Hemostasis01:24

Disorders of Hemostasis

711
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
711
Epistaxis01:30

Epistaxis

136
Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
136
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

139
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
139

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emergency in pediatric rheumatology: a narrative review.

Frontiers in medicine·2026
Same author

Exploring the Role of <i>Cissus quadrangularis</i> in Osteoporosis Management.

Orthopedic research and reviews·2026
Same author

A quantum logic gate framework for triosephosphate isomerase: Decoherence-induced toxicity.

Bio Systems·2026
Same author

Cardiovascular health in women: a consensus document of the Italian Cardiovascular Societies.

Journal of cardiovascular medicine (Hagerstown, Md.)·2026
Same author

Systemic ozone therapy improves the quality of life in patients with bladder pain syndrome.

Bladder (San Francisco, Calif.)·2025
Same author

A Case Report of Continuous Flumazenil Infusion in a Nonagenarian With Benzodiazepine Toxicity, Managed Outside Intensive Care.

Cureus·2025

Related Experiment Video

Updated: Jun 7, 2025

Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device
04:40

Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device

Published on: November 4, 2022

1.0K

Blue Rubber Bleb Nevus Syndrome Causing Small Bowel Bleeding.

Daniele Romanello1, Emanuele De Meo2, Francesco Molinario3

  • 1Internal Medicine, Ospedale San Pietro Fatebenefratelli, Rome, Italy. romanello.daniele@fbfrm.it.

Digestive Diseases and Sciences
|November 18, 2024
PubMed
Summary

Severe iron-deficiency anemia in a 79-year-old man was linked to Blue Rubber Bleb Nevus Syndrome (BRBNS). Surgical resection confirmed the rare vascular disorder causing gastrointestinal bleeding.

Keywords:
AnemiaBlue rubber bleb nevusGastrointestinal bleedingSmall bowelVascular structures

More Related Videos

Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects
07:34

Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects

Published on: May 11, 2011

14.0K
Application of Microwave Ablation in Laparoscopic Partial Splenectomy
03:49

Application of Microwave Ablation in Laparoscopic Partial Splenectomy

Published on: November 15, 2024

141

Related Experiment Videos

Last Updated: Jun 7, 2025

Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device
04:40

Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device

Published on: November 4, 2022

1.0K
Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects
07:34

Microsurgical Venous Pouch Arterial-Bifurcation Aneurysms in the Rabbit Model: Technical Aspects

Published on: May 11, 2011

14.0K
Application of Microwave Ablation in Laparoscopic Partial Splenectomy
03:49

Application of Microwave Ablation in Laparoscopic Partial Splenectomy

Published on: November 15, 2024

141

Area of Science:

  • Gastroenterology
  • Vascular Medicine
  • Surgical Pathology

Background:

  • Blue Rubber Bleb Nevus Syndrome (BRBNS) is a rare congenital disorder characterized by multiple venous malformations in the skin and internal organs.
  • Gastrointestinal bleeding is a common and potentially severe manifestation of BRBNS, often leading to iron-deficiency anemia.

Purpose of the Study:

  • To report a case of severe iron-deficiency anemia secondary to Blue Rubber Bleb Nevus Syndrome.
  • To highlight the diagnostic utility of capsule endoscopy and the role of surgical intervention in managing BRBNS-related gastrointestinal bleeding.

Main Methods:

  • A 79-year-old male patient presented with fatigue and melena, diagnosed with severe iron-deficiency anemia.
  • Diagnostic workup included capsule endoscopy, which identified jejunal submucosal vascular lesions and active ileal bleeding.
  • Exploratory laparoscopy was performed, leading to the resection of a 120 cm intestinal segment.

Main Results:

  • Capsule endoscopy revealed characteristic vascular anomalies consistent with BRBNS.
  • Surgical resection confirmed the presence of extensive jejunal and ileal vascular malformations.
  • The patient's anemia was attributed to chronic blood loss from these lesions.

Conclusions:

  • Blue Rubber Bleb Nevus Syndrome can present insidiously with severe anemia due to gastrointestinal bleeding.
  • Capsule endoscopy is a valuable tool for diagnosing BRBNS in the small intestine.
  • Surgical resection of affected intestinal segments may be necessary for definitive management.