Related Experiment Video
Updated: Jun 7, 2025
07:56
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
17.5K
Does higher serum 25-hydroxyvitamin D levels will harm bone mineral density?: a cross-sectional study
Bingcheng Xu1, Qiai Li2, Bo Luo1
1Department of Geriatrics, Wuhan Wuchang Hospital, Wuhan, 430063, China.
BMC Endocrine Disorders
|November 18, 2024
Summary
Optimal vitamin D levels for bone health differ by sex. For men, 84.8 nmol/L is ideal, while women need above 31.4 nmol/L to support bone mineral density (BMD).
Area of Science:
- Endocrinology and Bone Metabolism
- Nutritional Science
- Public Health
Background:
- Vitamin D is crucial for bone health and osteoporosis management.
- Optimal vitamin D supplementation strategies for maintaining bone mineral density (BMD) remain debated.
- This study investigates the relationship between serum 25-hydroxyvitamin D [25(OH)D] and BMD in adults.
Purpose of the Study:
- To determine the correlation between serum 25(OH)D levels and total BMD in a large adult population.
- To identify sex-specific optimal serum 25(OH)D thresholds for bone health.
Main Methods:
- Analysis of data from 11,375 adult participants in the National Health and Nutrition Examination Survey (NHANES) 2011-2018.
- Key variables included serum 25(OH)D levels and BMD.
- Multivariable logistic regression was employed to control for confounding factors.
Main Results:
- A U-shaped association was observed between serum 25(OH)D and BMD.
- In males, positive correlation with BMD was significant below 84.8 nmol/L (p < 0.0001).
- In females, positive correlation with BMD was significant below 31.4 nmol/L (p = 0.0010), with diminishing significance above this level.
Conclusions:
- The optimal serum 25(OH)D level for adult males is 84.8 nmol/L; higher levels do not enhance BMD.
- For adult females, serum 25(OH)D levels should be above 31.4 nmol/L to support BMD.
- Maintaining adequate vitamin D levels is essential for bone health in both men and women.
More Related Videos
10:46A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
10.7K
06:47Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
9.3K
Related Concept Videos
01:25Role of Vitamins in Maintaining Bone Health
3.2K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.2K
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
01:21Skeleton and Calcium Homeostasis
4.4K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.4K
01:23Role of Skin in Vitamin D Synthesis
5.0K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.0K
01:17Hormones and Bone Tissue
2.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.6K
01:31Essential Minerals for Bone Health
3.8K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
3.8K