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Updated: Jun 7, 2025
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Label-free Single Molecule Detection Using Microtoroid Optical Resonators
Published on: December 29, 2015
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Detection and Digital Resolution Counting of Nanoparticles with Optical Resonators and Applications in Biosensing
Miguel Ángel Aguirre1, Kenneth D Long2, Nantao Li3
1Department of Analytical Chemistry and Food Science and University Institute of Materials, Faculty of Science, University of Alicante, P.O. Box 99, 03080 Alicante, Spain.
Chemosensors (Basel, Switzerland)
|November 19, 2024
Summary
Optical nanostructures enable highly sensitive nanoparticle detection. This review covers methods for observing single nanoparticle interactions for applications like biomolecular sensing and viral load monitoring.
Area of Science:
- Nanotechnology
- Optical Sensing
- Biomolecular Interactions
Background:
- Nanoparticle interaction with electromagnetic fields is key for advanced sensing.
- Optical nanostructures facilitate single-nanoparticle detection and counting.
- Sensing relies on nanoparticle properties like dielectric permittivity, absorption, and scattering.
Purpose of the Study:
- To review fundamental sensing methods, device structures, and instruments for single-nanoparticle detection.
- To classify sensing approaches based on observing attachment/detachment events versus imaging.
- To highlight applications in biomolecular interaction studies, viral monitoring, and diagnostics.
Main Methods:
- Review of existing literature on nanoparticle-optical nanostructure interactions.
- Classification of sensing techniques based on detection mechanisms (event-based vs. imaging).
- Analysis of nanoparticle types including biomaterial, metal, and dielectric.
Main Results:
- Demonstration of single-nanoparticle detection limits and digital counting capabilities.
- Identification of diverse sensing approaches for nanoparticle interaction observation.
- Successful application in studying biomolecular interactions and viral monitoring.
Conclusions:
- Single-nanoparticle sensing using optical nanostructures offers high sensitivity and resolution.
- The reviewed methods and devices are crucial for advancing in vitro diagnostics.
- Future research can further leverage these techniques for precise biomolecule detection.
