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Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Amyloid Fibrils03:03

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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Neural Regulation01:37

Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Related Experiment Video

Updated: Jun 7, 2025

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
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Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

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Association of precuneus Aβ burden with default mode network function.

Liang Cui1, Zhen Zhang1, You-Yi Tu1

  • 1Department of Gerontology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|November 19, 2024
PubMed
Summary
This summary is machine-generated.

Amyloid-beta (Aβ) in the precuneus impacts brain network function and cognition. Early detection of Aβ deposition is crucial for monitoring Alzheimer's disease risk and cognitive decline.

Keywords:
Alzheimer's diseaseamyloid‐betacognitive declinedefault mode networkmild cognitive impairmentprecuneussubjective cognitive decline

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Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
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Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
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Area of Science:

  • Neuroscience
  • Alzheimer's Disease Research
  • Brain Imaging

Background:

  • The relationship between local amyloid-beta (Aβ) deposition in default mode network (DMN) regions and network/cognitive function is not well understood.
  • Investigating the precuneus (PRC) as a key DMN region is essential for understanding early Alzheimer's disease (AD) pathology.

Purpose of the Study:

  • To examine the association between precuneus (PRC) Aβ burden and DMN function.
  • To determine how PRC Aβ burden and DMN function relate to cognitive performance in preclinical AD.

Main Methods:

  • 1002 participants from the Chinese Preclinical Alzheimer's Disease Study underwent 18F-florbetapir PET, fMRI, and neuropsychological testing.
  • Correlations between PRC Aβ burden, DMN function, and cognitive function were analyzed.

Main Results:

  • A bidirectional relationship exists between PRC Aβ burden, DMN function/connectivity, and cognitive function.
  • DMN function is linked to PRC Aβ deposition even below the Aβ threshold, indicating early neural changes.
  • High PRC Aβ burden is associated with neural compensation and subsequent dysfunction.

Conclusions:

  • PRC Aβ deposition significantly disrupts neural networks, contributing to cognitive decline.
  • Early detection and monitoring of PRC Aβ burden are vital for assessing AD risk.
  • Changes in DMN function offer insights into AD progression and potential therapeutic targets.