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Related Concept Videos

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Updated: Jun 7, 2025

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"Development, optimization, and characterization of Eudragit-based nanoparticles for Dasatinib delivery".

Hemanth G1, Anasuya Patil1, Hariprasad Mg2

  • 1Department of Pharmaceutics, KLE College of Pharmacy, Bengaluru, India.

Journal of Biomaterials Science. Polymer Edition
|November 19, 2024
PubMed
Summary

Dasatinib-loaded nanoparticles (DST-NPs) show promise for breast cancer treatment. These nanoparticles improved drug bioavailability, targeted tumors effectively, and demonstrated significant anti-cancer efficacy in preclinical models.

Keywords:
CancerDST-NPsDasatinibEudragitnanoparticles

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Oncology

Background:

  • Breast cancer remains a leading cause of mortality worldwide, necessitating novel therapeutic strategies.
  • Conventional chemotherapy faces challenges including poor bioavailability and off-target toxicity.
  • Nanoparticle-based drug delivery systems offer potential solutions for enhancing cancer treatment efficacy.

Purpose of the Study:

  • To develop and characterize dasatinib-loaded nanoparticles (DST-NPs) using Eudragit L100 for improved breast cancer therapy.
  • To evaluate the in vitro and in vivo performance of DST-NPs.
  • To assess the pharmacokinetic, biodistribution, efficacy, and safety profiles of DST-NPs.

Main Methods:

  • Formulation of dasatinib-loaded nanoparticles (DST-NPs) using Eudragit L100.
  • Characterization of DST-NPs for particle size, zeta potential, and entrapment efficiency.
  • In vitro drug release, cytotoxicity assays (MTT), and stability studies.
  • In vivo pharmacokinetic, tissue distribution, efficacy (DMBA-induced mammary carcinoma model), hematologic, and histopathological analyses in rats.

Main Results:

  • Optimized DST-NPs showed favorable physicochemical properties (202.1 nm size, -18 mV zeta potential, 93.11% entrapment efficiency).
  • Sustained in vitro drug release, enhanced in vivo bioavailability (higher Cmax and AUC0-t), and improved tumor targeting were observed.
  • DST-NPs significantly reduced tumor volume, improved survival rates, exhibited favorable hematologic profiles, and restored normal tissue architecture.
  • Higher cytotoxicity against breast cancer cell lines (MCF-7, MDA-MB231, 4T1) with lower IC50 values compared to pure dasatinib.

Conclusions:

  • DST-NPs formulated with Eudragit L100 represent a promising nanocarrier for enhanced breast cancer treatment.
  • The developed nanoparticles offer improved drug delivery, efficacy, and safety profile compared to free dasatinib.
  • Further investigation into DST-NPs could lead to advanced therapeutic options for breast cancer patients.