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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Updated: Jun 7, 2025

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The evolution of post-infection mortality.

Chadi M Saad-Roy1,2, Andy White3, Mike Boots2,4

  • 1Miller Institute for Basic Research in Science, University of California, Berkeley, CA, USA.

Proceedings. Biological Sciences
|November 19, 2024
PubMed
Summary
This summary is machine-generated.

Post-infection mortality (PIM) after infections like COVID-19 can be evolutionarily favored, especially when it reduces reinfection susceptibility. Understanding PIM

Keywords:
eco-evolutionary modelpathogen evolutionpost-infection mortality

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Area of Science:

  • Evolutionary biology
  • Epidemiology
  • Pathogen dynamics

Background:

  • COVID-19 highlights significant post-infection mortality (PIM) risks.
  • The evolutionary drivers of PIM remain poorly understood.

Purpose of the Study:

  • To investigate the evolutionary conditions favoring post-infection mortality (PIM).
  • To model the interplay between PIM, during-infection mortality (DIM), and pathogen evolution.

Main Methods:

  • Utilized an eco-evolutionary model.
  • Simulated pathogen dynamics considering susceptible populations (never-infected and previously infected).
  • Analyzed trade-offs between mortality and reinfection susceptibility.

Main Results:

  • PIM is evolutionarily neutral unless linked to other factors.
  • PIM can modulate endemicity and pathogen characteristics.
  • A trade-off where increased mortality reduces reinfection susceptibility can favor PIM over DIM.

Conclusions:

  • Post-infection mortality (PIM) can readily evolve under specific conditions.
  • Susceptibility-mortality trade-offs offer a potential explanation for PIM's prevalence.
  • Considering diverse mortality sources is crucial for understanding pathogen evolution.