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Updated: Jun 7, 2025
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Determining Basal Energy Expenditure and the Capacity of Thermogenic Adipocytes to Expend Energy in Obese Mice
Published on: November 11, 2021
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Resting metabolic rate in obesity
LingHong Huang1, ZhiFeng Guo2, ZhengRong Jiang1
1Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, NO. 950 Donghai Street, Fengze District, Quanzhou 362000, Fujian, China.
Postgraduate Medical Journal
|November 19, 2024
Summary
Obesity is a growing global health threat with limited effective treatments. This review focuses on resting metabolic rate (RMR) as a key factor in obesity, exploring its influence and potential as a therapeutic target.
Area of Science:
- Metabolic disorders
- Obesity research
- Energy balance
Background:
- Rising global obesity rates pose significant health challenges.
- Current obesity interventions lack sustained long-term efficacy.
- Identifying novel therapeutic targets is crucial for sustainable obesity management.
Purpose of the Study:
- To elucidate the influence factors and mechanisms of resting metabolic rate (RMR) in obesity.
- To emphasize the effects of obesity treatments on RMR.
- To examine RMR alterations in specific obese populations.
Main Methods:
- Literature review on resting metabolic rate (RMR).
- Analysis of RMR's role in energy expenditure and balance.
- Investigation of RMR's association with weight gain and obesity-related diseases.
Main Results:
- Resting metabolic rate (RMR) accounts for 60%-75% of total energy expenditure.
- Individual heterogeneity in RMR exists, with low RMR linked to weight gain.
- Obesity treatment effects on RMR and RMR in special populations require further study.
Conclusions:
- Resting metabolic rate (RMR) is a critical factor in obesity and a potential therapeutic target.
- Understanding RMR's variability and response to treatment is key for effective obesity management.
- Further research into RMR's role in diverse obese populations is warranted.
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