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Updated: Jun 7, 2025

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
[Overactive bladder in the elderly]
G Krivoborodov G1,2, S Efremov N1,2, A Gontar A1,2
1Department of Urology and Andrology in N.I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia.
Abstract:
Overactive bladder (OAB) is a syndrome consisting of urgency, usually accompanied by urinary frequency and nocturia, with or without urgent incontinence, in absence of a causative infection or pathological conditions. The prevalence of OAB is approximately 11-19% in both men and women, and leads to a significant negative effect on health-related quality of life. The prevalence of OAB increases with age. The elderly population is unique, with increased medical comorbidities and the possibility for cognitive and functional deficits. Anticholinergics should be avoided in older adults as this class of drugs is associated with an increased risk of cognitive decline. Unfortunately, there is little data on the possibility of using intradetrusor injections of botulinum toxin, as well as tibial and sacral neuromodulation in elderly patients with OAB.
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