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Saoussen Zrour1, Amani Dridi1, Rim Grassa1

  • 1Rheumatology Department, CHU Fattouma Bourguiba, Faculty of Medicine of Monastir, University of Monastir, Tunisia.

La Tunisie Medicale
|November 20, 2024
PubMed
Summary
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Biologic disease-modifying antirheumatic drugs (bDMARDs) are primarily prescribed for axial spondylarthritis and rheumatoid arthritis in Tunisia. High costs associated with these advanced therapies present a considerable economic burden.

Area of Science:

  • Rheumatology
  • Health Economics
  • Pharmacoeconomics

Context:

  • Chronic inflammatory rheumatic diseases (CIRD) represent a significant health burden globally.
  • Biologic disease-modifying antirheumatic drugs (bDMARDs) are crucial for managing severe CIRD.
  • Understanding bDMARD prescription patterns and costs is vital for resource allocation.

Purpose:

  • To analyze bDMARD prescription trends in Tunisian CIRD patients.
  • To estimate the direct costs of bDMARD therapy.
  • To identify factors associated with bDMARD selection and cost.

Summary:

  • Analysis of 109 patients revealed axial spondylarthritis (44%) and rheumatoid arthritis (37.6%) as primary indications for bDMARDs.
  • Certolizumab pegol was the most prescribed agent (45%).
Keywords:
Axial spondylarthritisCostHealth InsuranceMolecular targeted therapyRheumatoid arthritisTumor Necrosis Factor Inhibitors

Related Experiment Videos

  • Prescription patterns correlated with regional rheumatologist distribution; no significant patient or prescriber-related factors influenced bDMARD choice.

    • Impact:

    • The study highlights the substantial economic impact of bDMARDs in Tunisia, with overspending linked to disease severity and patient demographics.
    • Findings can inform public health managers in resource allocation and cost-reduction strategies.
    • This data supports the development of medico-economic strategies for sustainable bDMARD access.