[Disease Caused by Filoviruses: An Update]
Rafael Marx de Andrade1, Andreia Paulos2, Emília Valadas3
1Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.
Acta Medica Portuguesa
|November 20, 2024
Summary
Marburg and Ebola viruses (Filoviridae family) cause severe, transmissible zoonotic diseases. This review enhances clinical knowledge for suspected filovirus disease (FD) cases, improving global outbreak preparedness.
Area of Science:
- Virology
- Zoonotic Diseases
- Public Health
Context:
- Marburg and Ebola viruses (Filoviridae family) are emerging zoonotic pathogens.
- High case fatality rates and transmissibility pose significant public health risks, including bioterrorism threats.
- Natural reservoirs include fruit bats, with transmission via direct contact with infected bodily fluids.
Purpose:
- To improve clinical knowledge and management strategies for suspected filovirus disease (FD).
- To enhance preparedness for potential global outbreaks of FD.
- To inform healthcare professionals on effective responses to filovirus threats.
Summary:
- Filovirus disease (FD) presents severe symptoms like mucocutaneous hemorrhage and multiorgan failure.
- Current treatment relies on supportive care, though specific therapies like monoclonal antibodies and vaccines exist for Zaire Ebola virus (EBOV).
- The term 'viral hemorrhagic fever' is being reconsidered due to variable clinical manifestations.
Impact:
- Enhanced surveillance and preparedness are crucial for effective global response to filovirus outbreaks.
- Improved clinical understanding will aid healthcare professionals in managing FD cases, even in non-endemic regions.
- Proactive measures are essential to mitigate the impact of these high-consequence pathogens.
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