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Derivatives of 1,3,3-trimethyl-6-azabicyclo-[3.2.1]octane with hypotensive activity. III
Abstract:
The synthesis of a series of alkyl and aryl thioureas (II) starting from 1,3,3-trimethyl-6-azabicyclo[3.2.1]octane is described. Some of alkyl thioureas showed a moderate hypotensive activity in rats. Effects on heart rate and hypoglycemic activity in rats, infiltration anesthesia and antiarrhythmic activity in mice are also reported.