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Functional precision medicine: the future of cancer care

Arlet M Acanda de la Rocha1, Noah E Berlow2, Diana J Azzam1

  • 1Department of Environmental Health Sciences, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, FL, USA.

Trends in Molecular Medicine
|November 20, 2024
PubMed

Insights

Functional precision medicine (FPM), integrating drug sensitivity tests with genomic data, is a feasible approach to identify cancer treatments. This method shows promise for accelerating care in recurrent and refractory cancers.

Area of Science:

  • Oncology
  • Genomics
  • Pharmacology

Background:

  • Recurrent and refractory cancers present significant treatment challenges.
  • Genomic profiling and ex vivo drug sensitivity testing are emerging tools in oncology.

Purpose of the Study:

  • To review the history and recent advancements in Functional Precision Medicine (FPM).
  • To explore barriers hindering the clinical utility and accessibility of FPM for various cancer types.

Main Methods:

  • Literature review and synthesis of current research on FPM.
  • Analysis of clinical data and expert opinions on FPM implementation.

Main Results:

  • Functional precision medicine (FPM) is feasible and shows potential for accelerated application.
  • Significant barriers exist for expanding FPM's clinical utility and accessibility.

Conclusions:

  • FPM offers a viable strategy for personalized cancer treatment selection.
  • Addressing identified barriers is crucial for broader FPM adoption in pediatric, adolescent, and adult oncology.
Keywords:
adult cancerartificial intelligencedrug sensitivity testingfunctional precision medicinepediatric cancer

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