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Coacervate-pore complexes for selective molecular transport and dynamic reconfiguration.

Hao Wang1,2,3, Hui Zhuang4, Wenjing Tang5

  • 1South China Advanced Institute for Soft Matter Science and Technology (AISMST), School of Emergent Soft Matter, South China University of Technology, Guangzhou, 510640, China.

Nature Communications
|November 20, 2024
PubMed
Summary

Researchers created coacervate-pore complexes (CPCs) that mimic nuclear pore complexes (NPCs) for selective molecule transport. These dynamic liquid-based systems offer tunable permeability and self-healing properties for advanced filtration applications.

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Area of Science:

  • Materials Science
  • Biomimetic Engineering
  • Supramolecular Chemistry

Background:

  • Growing interest in liquid-state coacervates and condensates for advanced materials.
  • Limited exploration of confining these liquid phases within solid pores for selective permeation.
  • Nuclear Pore Complexes (NPCs) serve as a biological model for selective transport.

Purpose of the Study:

  • To design and construct coacervate-pore complexes (CPCs) with tunable permeability.
  • To mimic the selective transport capabilities of nuclear pore complexes (NPCs).
  • To explore the potential of liquid-based systems for advanced filtration and separation.

Main Methods:

  • Spontaneous imbibition of coacervate droplets into various solid-state pore types driven by capillarity.
  • Demonstration of CPC formation across diverse coacervate systems and pore architectures.
  • Characterization of guest molecule transport modulation based on coacervate affinity.

Main Results:

  • Universal CPC formation achieved across 19 coacervate systems and 5 pore types.
  • CPCs successfully regulated through-pore transport, mimicking NPC selectivity via a fluidic network.
  • Liquid nature of CPCs allows for dynamic healing and rapid phase transitioning for permeability control.

Conclusions:

  • Coacervate-Pore Complexes (CPCs) represent a novel approach to creating artificial selective transport systems.
  • The liquid-based nature of CPCs offers advantages over solid mimics, including self-healing and dynamic regulation.
  • This work establishes a foundation for developing liquid-based NPC analogs using synthetic coacervates and biomolecular condensates.