Pd/NHC sequentially catalyzed atroposelective synthesis of planar-chiral macrocycles
Gongming Yang1, Shangde Liu1, Shujie Ji1
1School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Ministry of Education, Tsinghua University Beijing 100084 China wangjian2012@tsinghua.edu.cn.
Abstract:
Planar-chiral macrocycles play a pivotal role in host-guest chemistry and drug discovery. However, compared with the synthesis of other types of chiral compounds, the asymmetric construction of planar-chiral macrocycles still remains a forbidding challenge. Herein, we report a sequential palladium and N-heterocyclic carbene catalysis to build planar-chiral macrocycles. This protocol features broad scope and good functional group tolerance, and allows a rapid assembling of planar-chiral macrocycles with excellent enantioselectivities.
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