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Updated: Jun 7, 2025

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
Nanozymes: a promising solution for dental antibacterial applications
Lipeng Liu1,2, Yaoyuan Zhang1, Tianjuan Ju1
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, School of Stomatology, The Fourth Military Medical University China lianwu@fmmu.edu.cn.
Abstract:
Dental diseases pose significant public health challenges globally, affecting millions with conditions exacerbated by microbial-induced inflammation. Traditional natural enzymes, despite their antibacterial and anti-inflammatory capabilities, are limited by operational stability and environmental sensitivity. This review explores the revolutionary realm of nanozyme-artificial enzymes made from nanomaterials-which offer enhanced stability, cost-effectiveness, and ease of modification. We discuss the advent of nanozymes since their first recognition in 2007, emphasizing their enzyme-mimicking capabilities and applications in dental medicine, particularly for dental caries, pulpitis, periodontitis and peri-implantitis. This paper presents a comprehensive analysis of nanozymes' classification, mechanisms, and emerging applications, shedding light on their potential to revolutionize dental antibacterial treatments and addressing current challenges and future perspectives in their development.
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