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Related Concept Videos

Super-resolution Fluorescence Microscopy01:37

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been developed.
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Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...

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Rechargeable Afterglow Superclusters for NIR-Excitable Repetitive Phototherapy.

Lulu Yue1, Yilin Liu2, Jing Wang1

  • 1School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.

Nano Letters
|November 21, 2024
PubMed
Summary

Researchers developed near-infrared-excitable afterglow superclusters for biomedical applications. These superclusters enable deep-tissue photodynamic therapy, improving treatment efficiency and inhibiting tumor growth.

Keywords:
NIRPersistent luminescencephotodynamic therapysuperclusterupconversion

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Afterglow luminescence offers prolonged emission, reduced autofluorescence, and minimized photodamage, making it attractive for biomedical applications.
  • Current persistent luminescence often requires high-energy excitation (UV/visible light), limiting tissue penetration and therapeutic efficacy.
  • A need exists for afterglow materials excitable by near-infrared (NIR) light for deeper tissue penetration.

Purpose of the Study:

  • To develop novel NIR-excitable afterglow superclusters (UCZG-SCs) for enhanced photodynamic therapy (PDT).
  • To demonstrate a flexible fabrication strategy for tunable supercluster properties.
  • To create an injectable implant for in-body PDT applications.

Main Methods:

  • A one-pot surface segregation strategy was employed to assemble spinel-phase (Zn1.1Ga1.8Ge0.1O4:Cr3+) and hexagonal-phase (NaYF4:Yb,Tm@NaLuF4:Y) nanoparticles into NIR-excitable afterglow superclusters.
  • The methodology allows for flexible fabrication of superclusters with varying size, composition, and luminescent profiles, independent of crystal lattice similarity.
  • An injectable persistent implant was created by embedding UCZG-SCs in a poly(lactic-co-glycolic acid)/N-methylpyrrolidone oleosol.

Main Results:

  • Successfully constructed NIR-excitable afterglow superclusters (UCZG-SCs) with excellent charging-recharging stability.
  • Demonstrated the feasibility of an injectable persistent implant for in-body PDT.
  • Achieved repetitive phototherapy under periodic 980 nm light illumination, significantly improving phototherapeutic efficiency and restraining tumor growth.

Conclusions:

  • The developed one-pot strategy provides a flexible platform for fabricating diverse NIR-excitable persistent superclusters.
  • The UCZG-SCs and their injectable implant formulation show great promise for advanced photodynamic therapy.
  • This approach enables efficient, repetitive phototherapy with enhanced tumor growth inhibition using deep-tissue-penetrating NIR light.