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Updated: Jun 7, 2025

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Thermal CO Release Reactivity of a π-Extended Flavonol Anion
Stephen N Anderson1, C Taylor Dederich1, Tomasz Borowski2
1Department of Chemistry & Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, United States.
Abstract:
The π-extended flavonol Flav-1 (1) undergoes reaction with KOH or KO2 to form 1-, which reacts with O2 at ambient temperature, resulting in CO release and depside formation. Mechanistic and DFT studies support a reaction pathway involving reaction of 1- with O2 on the triplet energy surface in the rate-determining step. Formation of a cyclic peroxide leads to CO extrusion. These studies indicate that if formed in biological environments, 1- will release CO in the absence of light illumination.
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