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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Related Experiment Video

Updated: May 10, 2026

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats

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Published on: November 7, 2017

Patterned electrical brain stimulation by a wireless network of implantable microdevices.

Ah-Hyoung Lee¹, Jihun Lee¹, Vincent Leung²

¹School of Engineering, Brown University, Providence, RI, USA.

Nature Communications

|November 21, 2024

Summary

Researchers developed a wireless brain-computer interface using implanted microchips for precise electrical stimulation. This technology enables targeted neural activation, advancing brain-computer interface capabilities for potential therapeutic applications.

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Area of Science:

Neuroscience
Biomedical Engineering
Electrical Engineering

Background:

Brain-computer interfaces (BCIs) aim to transmit information to neural circuits electronically.
Current methods for neural stimulation face challenges in spatial precision and wireless control.
Targeting specific cortical areas requires advanced techniques for localized current delivery.

Purpose of the Study:

To introduce a novel wireless approach for multipoint patterned electrical microstimulation.
To demonstrate the feasibility of epicortically implanted microchip networks for targeted cortical stimulation.
To investigate the effects of patterned electrical stimulation on animal behavior.

Main Methods:

Developed a network of sub-millimeter wireless silicon microchips for epicortical implantation.
Each microchip harvests radio-frequency energy and delivers biphasic current via integrated microwires.
Implemented a collision-free bitmap wireless communication protocol for precise control of stimulation parameters (amplitude, period, rate) with sub-millisecond latency.
Chronically implanted a network of 30 wireless stimulators in a freely moving rat for three months.

Main Results:

Successfully demonstrated chronic wireless patterned electrical microstimulation in a rodent model.
Achieved precise, localized current delivery to targeted cortical areas.
Explored the effects of stimulation on trained animal behavior.
Operated the system at average radio-frequency powers below regulatory safety limits.

Conclusions:

The wireless microchip network represents a viable technology for advanced brain-computer interfaces.
This approach offers precise spatial control over neural stimulation.
The technology holds promise for future therapeutic applications in neuroscience and neurology.