Studies on the effects of MJ-9184-1 in man

A new beta 2-adrenergic receptor stimulating drug, 2-hydroxy-5-[1-hydroxy-2-(2-methyl-1-phenyl-2-propyl-amino)-ethyl]-methanesulfonanilide hydrochloride (MJ-9184-1), was found to be a potent bronchodilator in man. In double-blind cross-over study including placebo, 0.25 mg and 0.50 mg MJ-9184-1 and involving ten patients with stable chronic obstructive lung disease with reversible airways obstruction, MJ-9184-1 caused a fast-appearing and long-lasting bronchodilator effect. The oral intake of 0.50 mg MJ-9184-1, compared to 0.25 mg, caused a more rapid effect and a more pronounced bronchodilation; 0.50 mg MJ-9184-1 also caused some elevation of the pulse rate. The effect was not seen after 0.25 mg MJ-9184-1.