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Altered CSF protein pattern in a case of mycosis fungoides with nervous system involvement
Italian Journal of Neurological Sciences
|February 1, 1986
Abstract:
We report the clinical, neurophysiological and CSF study in a case of mycosis fungoides with nervous system involvement. The CSF contained an abnormal protein of molecular weight 22000 that was not in the patient's serum or in the CSF of control subjects and that disappeared after intrathecal immunosuppressive therapy. The nature of this protein is discussed in the light of hypothesis regarding the pathogenesis of the disease.
Insights
This study details a rare case of mycosis fungoides affecting the nervous system. Researchers identified a unique abnormal protein in cerebrospinal fluid (CSF) that resolved with treatment.
Area of Science:
- Neurology
- Oncology
- Biochemistry
Background:
- Mycosis fungoides is a type of T-cell lymphoma that can rarely involve the central nervous system.
- Nervous system involvement in mycosis fungoides presents diagnostic challenges.
- Understanding the molecular mechanisms of neuroinvasion is crucial for effective treatment.