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Updated: Jun 6, 2025

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The association between fatigue and cardiometabolic diseases: Insights from the UK biobank study

Keyu Bian1, Pan Zhang2, Gelin Xu3

  • 1Department of Neurology, Wujin TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Changzhou, Jiangsu, China; Department of Neurology, Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China; Department of Neurology, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.

Journal of Affective Disorders
|November 22, 2024
PubMed

Insights

Fatigue is linked to increased cardiometabolic disease risk. This bidirectional relationship highlights the importance of fatigue in heart health and metabolic conditions.

Area of Science:

  • Cardiovascular research
  • Metabolic disease research
  • Genetics and epidemiology

Background:

  • Cardiometabolic diseases (CMD) pose significant global health risks.
  • Fatigue is a common symptom linked to CMD, but its relationship is unclear.
  • Investigating fatigue's role in CMD is crucial for public health.

Purpose of the Study:

  • To investigate the relationship between fatigue and cardiometabolic diseases (CMD).
  • To explore if fatigue is a risk factor for or consequence of CMD.
  • To utilize observational and genetic methods to clarify this association.

Main Methods:

  • Observational study using UK Biobank data.
  • Bidirectional Mendelian randomization (MR) approach to assess causality.
  • Genome-wide association studies (GWAS) and various MR sensitivity analyses were performed.

Main Results:

  • Observational data showed fatigue significantly increased risk for stroke, T2D, CAD, and HF.
  • MR analyses confirmed a causal link between fatigue and CMD.
  • Type 2 diabetes (T2D) was associated with increased fatigue levels; lipid metabolites mediated this relationship.

Conclusions:

  • A bidirectional relationship exists between fatigue and CMD.
  • Fatigue is an important factor to consider in cardiometabolic health.
  • Further research into fatigue as a clinical marker for CMD is warranted.
Abstract

Keywords:
Cardiometabolic diseaseDiabetesFatigueHeart failureMendelian randomizationStroke

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