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Increased circulating serpinB1 levels in children with overweight/obesity are associated with obesity-related
Qing Li1, Zhuxi Li1, Shusen Guo1
1Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Insights
Elevated serum serpinB1 levels are linked to childhood obesity and associated metabolic issues. Higher serpinB1 indicates an increased risk for overweight and obesity in children.
Area of Science:
- Pediatric Endocrinology
- Metabolic Health
- Obesity Research
Background:
- Serine protease inhibitor B1 (serpinB1) levels are elevated in obese mice, promoting beta-cell proliferation.
- Limited data exists on serum serpinB1 in children with obesity.
- This study investigates serum serpinB1 in overweight/obese children and its relation to obesity markers.
Purpose of the Study:
- To determine serum serpinB1 levels in children with overweight/obesity.
- To examine the association between serum serpinB1 and obesity-related parameters.
- To assess the risk of overweight/obesity associated with elevated serpinB1.
Main Methods:
- Recruited 54 overweight/obese children and 36 normal-weight controls (aged 6-14).
- Measured anthropometric, glucolipid metabolic, sex hormone, and serum serpinB1 levels.
- Analyzed associations using correlation and binary regression.
Main Results:
- Serum serpinB1 was significantly higher in overweight/obese children (2.03 vs. 1.41 ng/mL, p<0.001).
- SerpinB1 correlated positively with BMI, BMI Z-score, triglycerides, uric acid, fasting insulin, C-peptide, and HOMA-IR.
- Elevated serpinB1 increased the risk of childhood overweight/obesity (OR 4.132, p=0.015) after adjustments.
Conclusions:
- Circulating serpinB1 is significantly elevated in overweight/obese children.
- Serum serpinB1 is positively associated with key glucolipid metabolic parameters.
- These findings highlight a strong link between serum serpinB1 and childhood obesity.
Background:
Circulating serpinB1 levels are increased in obese mice and have been shown to promote β-cell proliferation in several species. However, the data on serum serpinB1 levels in children with obesity are scarce. This study aimed to determine serum serpinB1 levels in children with overweight/obesity, and to study its association with obesity-related parameters.
Methods:
A total of 54 children with overweight/obesity and 36 normal-weight healthy controls aged 6-14 were recruited in this study. Anthropometric parameters, glucolipid metabolic biochemical parameters, sex hormones, and serum serpinB1 levels were measured in all subjects. The association of serum serpinB1 levels with obesity-related parameters and the risk of overweight/obesity were analyzed using correlation analysis and binary regression analysis, respectively.
Results:
The serum serpinB1 level in overweight/obese children was notably greater than in normal-weight controls (2.03 ± 0.70 vs. 1.41 ± 0.58 ng/mL, p < 0.001). SerpinB1 levels were positively correlated with body mass index (BMI), BMI Z-score, triglyceride (TG), uric acid, fasting insulin, C-peptide, and homeostasis model assessment of insulin resistance (HOMA-IR) levels. Additionally, we found that elevated circulating serpinB1 levels were associated with the increased risk of childhood overweight/obesity even after adjustment for age, gender, and HOMA-IR (odds ratio, 4.132; 95% confidence interval, 1.315-12.983; p = 0.015).
Conclusions:
Circulating serpinB1 level was significantly increased in children with overweight/obesity and positively associated with obesity-related glucolipid metabolic parameters. These results indicate a close association between serum serpinB1 concentrations and childhood overweight/obesity.
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