Neolignan Kadsurenin F Modulates Proteostatic Pathways and Possesses Potent Anti-Inflammatory Properties
Zoi Evangelakou1, Stefan Schwaiger2, Despoina D Gianniou1
1Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Athens, 15784, Greece.
Chemistry & Biodiversity
|November 23, 2024
Summary
Kadsurenin F, isolated from Piper kadsura, suppresses proteasome function and reduces inflammation. This natural compound shows potential for developing new anti-inflammatory drugs and proteasome inhibitors.
Area of Science:
- Natural Product Chemistry
- Pharmacology
- Molecular Biology
Background:
- Kadsurenin F is a neolignan found in Lauraceae and Piper species.
- Piper kadsura is traditionally used for inflammatory conditions.
- Previous research indicates anti-inflammatory properties of P. kadsura extracts.
Purpose of the Study:
- To isolate kadsurenin F from P. kadsura.
- To investigate the biological activities of kadsurenin F, focusing on proteasome function and inflammation.
- To assess the potential of kadsurenin F as a therapeutic agent.
Main Methods:
- Isolation of kadsurenin F from Piper kadsura.
- Assay of proteasome activity in human fibroblasts and Drosophila melanogaster.
- Evaluation of anti-inflammatory effects in RAW 264.7 macrophage cells stimulated with lipopolysaccharide (LPS).
Main Results:
- Kadsurenin F was isolated as an active component of P. kadsura.
- The compound increased oxidative load and suppressed proteasome functionality in human fibroblasts and Drosophila.
- Kadsurenin F reversed inflammatory phenotypes, inhibited nitric oxide (NO) production, and suppressed proteasome activity in LPS-stimulated macrophages.
Conclusions:
- Kadsurenin F exhibits both proteasome inhibitory and anti-inflammatory activities.
- The kadsurenin F scaffold is a promising candidate for developing novel therapeutic agents.
- Further research into kadsurenin F could lead to new treatments for inflammatory diseases and proteasome-related disorders.
Related Concept Videos
01:31Transducer Mechanism: Nuclear Receptors
1.3K
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
1.3K
01:37Neural Regulation
39.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.1K
01:19Antiasthma Drugs: Leukotriene Modifiers
245
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
245
02:26NF-κB-dependent Signaling Pathway
7.2K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.2K
02:39lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K