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Updated: Jun 6, 2025

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
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Allosteric substrate release by a sialic acid TRAP transporter substrate binding protein.

Niels Schneberger1, Philipp Hendricks1, Martin F Peter1,2

  • 1Institute of Structural Biology, University of Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.

Communications Biology
|November 23, 2024
PubMed
Summary

Researchers developed nanobodies targeting sialic acid transporters in Vibrio cholerae and Haemophilus influenzae. These nanobodies inhibit pathogen colonization by blocking essential nutrient uptake, offering new drug design strategies.

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