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MORE ON DEEP HEMATOMAS IN PATIENTS WITH COVID-19: CASE SERIES

K Lipatov1, E Komarova1, E Solov'eva1

  • 1Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Russian Federation.

Georgian Medical News
|November 24, 2024
PubMed

Insights

COVID-19 can cause a dangerous imbalance in blood clotting, leading to both thrombosis and severe bleeding. This study highlights the occurrence of deep hematomas in patients, complicating infection and increasing mortality risks.

Area of Science:

  • Medicine
  • Hematology
  • Infectious Diseases

Background:

  • COVID-19 infection can disrupt the hemocoagulation system.
  • The exact nature of this imbalance, whether thrombosis or hemorrhage prevails, remains unclear.
  • Deep hematomas have been increasingly reported in COVID-19 patients, necessitating further investigation.

Purpose of the Study:

  • To investigate the characteristics and outcomes of hematoma formation in hospitalized COVID-19 patients.
  • To analyze the coagulation status and mortality associated with hematoma development during COVID-19 infection.

Main Methods:

  • Observation of 7 COVID-19 patients who developed hematomas between October 2020 and January 2021.
  • Assessment of patient severity using SOFA and Caprini scales, and treatment with therapeutic doses of calcium nadroparin.
  • Diagnostic imaging (ultrasound, CT) and analysis of coagulograms, including D-dimer levels.

Main Results:

  • Seven patients (2.1% of hospitalized) developed hematomas, with 5 cases of deep hematomas up to 340 ml.
  • Median time to hematoma onset was 7 days; 3 patients with D-dimer >4000 ng/ml had fatal outcomes with pulmonary artery thrombosis.
  • Mortality rate in patients with hematomas was 42.9%, significantly higher than the hospital average of 7.1%.

Conclusions:

  • COVID-19 is characterized by a coagulation imbalance involving both thrombotic and hemorrhagic complications.
  • Deep hematomas are a poorly understood manifestation of severe COVID-19 that significantly worsens patient prognosis.
  • The findings underscore the complex hemostatic challenges posed by COVID-19 infection.
Abstract

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