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Updated: Jun 6, 2025
Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
Published on: January 29, 2014
Beyond the Norm: Gastroenteritis-Induced Atypical Hemolytic Uremic Syndrome in the Absence of Complement Dysfunction
Rita Bernardino1, Rodrigo Leão2,3, Angela Ghiletchi4
1Internal Medicine, Hospital Curry Cabral - Centro Hospitalar Universitário de Lisboa Central, Lisboa, PRT.
Abstract:
Atypical hemolytic uremic syndrome (aHUS) is a complex disorder characterized by thrombotic microangiopathy, typically driven by complement dysregulation. While most cases of aHUS are linked to genetic abnormalities in the complement system, sporadic instances occur without identifiable genetic or complement involvement. This report discusses the case of a 38-year-old woman who developed aHUS following gastroenteritis, marked by acute kidney injury requiring dialysis, yet displayed normal complement levels. This case highlights the diagnostic and management challenges in aHUS when traditional disease markers are absent and emphasizes the importance of tailored therapeutic approaches.
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