Study of Coagulation Parameters in Gastrointestinal Malignancies

Introduction  Gastrointestinal (GI) malignancies represent a diverse group of cancers affecting various parts of the digestive system. These malignancies encompass an important burden of cancer incidence and mortality globally, contributing to substantial morbidity and mortality worldwide. Studying the coagulation parameters of patients having GI malignancies is crucial for several reasons. It allows to identify the patients at an increased risk of thrombotic complications, enabling clinicians to implement appropriate prophylactic measures, such as anticoagulant therapy or mechanical thromboprophylaxis. Aim  To study coagulation parameters in patients diagnosed with GI malignancies. Materials and methods The present study is a two-year prospective observational study, carried out in the Department of Pathology in our tertiary care institute from July 2022 to June 2024 to investigate the coagulation profile in patients diagnosed with GI malignancies. A total of 86 cases were studied. Results  A significant increase in the mean values of coagulation parameters was noted with an increase in the grade of malignancy. Conclusion  Early examination for the presence of coagulation abnormalities can help to prevent morbidity and mortality and other bleeding diathesis in GI malignancies as alterations in the coagulation pathway can lead to lethal complications.