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Updated: Jun 6, 2025
06:23
Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
Published on: August 4, 2018
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Study of Coagulation Parameters in Gastrointestinal Malignancies
Gauri Patil1, Sujata R Kanetkar1
1Department of Pathology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Cureus
|November 25, 2024
Summary
Coagulation abnormalities are common in gastrointestinal (GI) malignancies. Early detection of these changes in GI cancer patients can help prevent serious bleeding complications.
Area of Science:
- Oncology
- Hematology
- Gastroenterology
Background:
- Gastrointestinal (GI) malignancies pose a significant global health burden.
- Coagulation disorders are frequently observed in cancer patients.
- Understanding these changes is vital for managing thrombotic risks.
Purpose of the Study:
- To investigate coagulation parameters in patients with GI malignancies.
- To correlate coagulation status with the grade of GI cancer.
Main Methods:
- A two-year prospective observational study.
- Involved 86 patients diagnosed with GI malignancies.
- Coagulation profiles were analyzed in a tertiary care setting.
Main Results:
- A significant increase in mean coagulation parameter values was observed.
- This increase correlated positively with the increasing grade of malignancy.
Conclusions:
- Early screening for coagulation abnormalities is recommended in GI malignancy patients.
- Identifying and managing these alterations can reduce morbidity and mortality.
- Coagulation pathway changes can lead to life-threatening complications in GI cancers.
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