Postoperative Pain at Discharge From the Post-anesthesia Care Unit: A Case-Control Study

Despite advancements in postoperative pain management, approximately 20% of patients still experience severe pain within the first 24 hours post-surgery. Previous studies utilizing machine learning have shown promise in predicting postoperative pain with various models. This study investigates postoperative pain predictors using a machine learning approach based on physiological indicators and demographic factors in a Mexican cohort.

We conducted a retrospective case-control study to assess pain determinants at Post-anesthesia Care Unit (PACU) discharge at Hospital Ángeles Lomas in Mexico City. Data were collected from 550 patients discharged from the PACU, including 292 cases and 258 controls, covering a range of surgical procedures and illnesses. Machine learning techniques were employed to develop a predictive model for postoperative pain. Physiological responses, such as blood pressure, heart rate, respiratory rate, and anesthesia type, were recorded prior to PACU admission.

Significant differences were found between cases and controls, with factors such as sex, anesthesia type, and physiological responses influencing postoperative pain. Visual analog scale (VAS) scores at PACU admission were predictive of pain at discharge.

Our findings reinforce existing literature by highlighting sex-based disparities in pain experiences and the influence of anesthesia type on pain levels. The logistic regression model developed, incorporating physiological responses and sex, shows potential for refining pain management strategies. Limitations include the lack of detailed surgical data and psychological factors, and validation in a prospective cohort. Future research should focus on more comprehensive predictive models and longitudinal studies to further improve postoperative pain management.