HPV self-sampling for cervical cancer screening in China: A multi-center study

Area of Science:

• Gynecology
• Public Health
• Virology

Background:

• Research on human papillomavirus (HPV) self-sampling in diverse Chinese populations is limited.
• HPV self-sampling offers a novel approach for collecting cervical cells.

Purpose of the Study:

• To assess the accuracy and acceptability of HPV self-sampling in China.
• To analyze HPV infection patterns across different demographics.

Main Methods:

• Recruited 5417 women aged 25-65 from 8 Chinese provinces.
• Collected paired clinician and self-samples for HPV genotyping (23 types) via PCR.
• Administered a questionnaire on HPV self-sampling acceptance.

Main Results:

• Crude agreement between self- and clinician-sampling was 93.06%.
• 43.79% of women preferred self-sampling; 67.59% preferred performing it at the hospital.
• HPV 52, 58, 16, 39, and 68 were the most prevalent genotypes, with the highest infection rate in the 25-30 age group.

Conclusions:

• HPV self-sampling is a viable supplement to traditional cervical screening in China.
• Clinician support and clear guidance are crucial for effective implementation.
• Screening and vaccination strategies may need adaptation for diverse populations.