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Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool
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Exosomal circular RNAs in tumor microenvironment: An emphasis on signaling pathways and clinical opportunities

Junshu Li1, Wencheng Zhou2, Huiling Wang1

  • 1Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy West China Hospital, Sichuan University Chengdu China.

Medcomm
|November 25, 2024
PubMed

Insights

Exosomal circular RNAs (circRNAs) are key regulators in cancer progression and the tumor microenvironment. These stable molecules show promise as diagnostic biomarkers and therapeutic targets for various cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Exosomes mediate intercellular communication by transferring genetic material, influencing cancer malignancy.
  • Exosomal circular RNAs (circRNAs) play critical roles in carcinogenesis, affecting tumor growth, metastasis, and drug resistance.

Purpose of the Study:

  • To review the regulatory roles of exosomal circRNAs in tumor progression and the tumor microenvironment (TME).
  • To summarize the intercellular transfer and impact of exosomal circRNAs within the TME.
  • To highlight the potential of exosomal circRNAs as biomarkers and therapeutic strategies in cancer.

Main Methods:

  • Literature review of recent studies on exosomal circRNAs in cancer.
  • Analysis of exosomal circRNA involvement in tumor-related signaling pathways.
  • Examination of exosomal circRNA transmission among cells in the TME.

Main Results:

  • Exosomal circRNAs regulate key cancer processes including growth, metastasis, angiogenesis, and immune escape.
  • Intercellular transfer of exosomal circRNAs among tumor cells, stromal cells, immune cells, and microbiota impacts tumor initiation and progression.
  • High stability and presence in biofluids make exosomal circRNAs promising diagnostic and prognostic biomarkers.

Conclusions:

  • Exosomal circRNAs are crucial regulators of cancer development and progression within the TME.
  • Exosomal circRNAs offer potential as non-invasive biomarkers for cancer diagnosis and prognosis.
  • Targeting exosomal circRNAs presents novel therapeutic strategies for cancer treatment.
Keywords:
biomarkercircRNAexosometumor microenvironmenttumor therapy

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