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Related Experiment Video

Updated: Jun 11, 2026

Vascular Organoid Generation from Human-Induced Pluripotent Stem Cells
04:41

Vascular Organoid Generation from Human-Induced Pluripotent Stem Cells

Published on: December 13, 2024

Advances in vascularized organoids.

Lanlin Shen1, Jinhu Ma, Xiao Wei

  • 1Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Chinese Medical Journal
|June 10, 2026
PubMed
Summary
This summary is machine-generated.

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Vascularized organoids show promise for regenerative medicine, but challenges in network integration and maturity persist. Future research should focus on advanced vascularization strategies for clinical translation.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Organoid technology has advanced regenerative medicine, disease modeling, and drug screening.
  • The absence of vascular networks in organoids hinders scalability and physiological relevance.
  • Vascularization is critical for nutrient delivery and growth maintenance in organoids.

Purpose of the Study:

  • To review current strategies for organoid vascularization.
  • To identify challenges and limitations in existing methods.
  • To propose future directions for developing clinically relevant vascularized organoids.

Main Methods:

  • Co-culture techniques
  • Transcription factor induction
  • Microfluidic technologies
Keywords:
3D bioprintingCo-cultureMicrofluidic technologyVascularized organoids

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Last Updated: Jun 11, 2026

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Optimization of Renal Organoid and Organotypic Culture for Vascularization, Extended Development, and Improved Microscopy Imaging
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  • Biomaterial scaffold applications

    • Main Results:

    • Various methods partially address organoid vascularization challenges.
    • Distinct advantages are observed across different organoid types.
    • Limitations include insufficient vascular network integration and functional maturity.

    Conclusions:

    • Further development of multi-tiered vascular networks is needed.
    • Smart biomaterials and personalized approaches are promising.
    • Translating vascularized organoids to clinical practice requires continued research and development.