COMPARISON OF FAILURE RATE OF TEMPORARY ANCHORAGE DEVICES PLACED WITH PLATELET RICH PLASMA AND PLACEBO OVER SIX...

Area of Science:

• Orthodontics
• Biomaterials Science

Background:

• Temporary anchorage devices (TADs) are crucial for orthodontic treatment success.
• Platelet-rich plasma (PRP) is utilized in oral surgery to enhance healing.
• The stability of TADs coated with PRP requires further investigation.

Purpose of the Study:

• To compare the 6-month stability of TADs coated with Platelet-Rich Plasma (PRP) versus Platelet-Poor Plasma (PPP) as a placebo.
• To evaluate the efficacy of PRP in enhancing TAD stability during orthodontic treatment.

Main Methods:

• A 6-month, triple-blinded, split-mouth randomized clinical trial involving 25 patients and 50 TADs.
• TADs were inserted with either PRP or PPP (placebo) into the pilot hole.
• TAD stability was assessed monthly for six months, with patients reporting any failures.

Main Results:

• Overall, 5 out of 50 TADs (10%) failed during the study period.
• Failure rates were 8% for the left side and 2% for the right side.
• The failure rate for PRP was 8% (2/25 TADs) compared to 12% (3/25 TADs) for PPP (placebo). Mean failure days were 6.50±9.192 for PRP and 46.00±3.22 for PPP.

Conclusions:

• No significant difference was observed in the stability of TADs treated with PRP compared to PPP (placebo).
• Factors like gender and operator handedness did not significantly impact TAD stability.
• Further research may be needed to explore potential benefits of PRP in specific clinical scenarios.