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Related Experiment Videos

Relapsing pseudomembranous colitis.

R Holmes, W J Byrne

    Journal of Pediatric Gastroenterology and Nutrition
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Recurrent Clostridioides difficile infection (CDI) can occur in children treated with vancomycin for pseudomembranous colitis. This case highlights a child experiencing CDI relapse after initial treatment, emphasizing the need for vigilance.

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    Area of Science:

    • Pediatric Gastroenterology
    • Infectious Diseases
    • Microbiology

    Background:

    • Pseudomembranous colitis caused by Clostridioides difficile (C. diff) is common in children, typically treated with oral vancomycin.
    • Relapse of C. diff infection is documented in adults but less frequently reported in pediatric cases.
    • Initial vancomycin treatment often leads to symptom resolution.

    Observation:

    • A child diagnosed with pseudomembranous colitis experienced recurrent diarrhea after completing oral vancomycin therapy.
    • Stool cultures initially negative for C. diff became positive upon recurrence of symptoms.
    • The patient's symptoms resolved after a second course of vancomycin.

    Findings:

    • This case documents the recurrence of C. diff infection in a pediatric patient following standard vancomycin treatment.

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  • Negative stool cultures post-treatment do not entirely rule out the possibility of relapse.
  • Successful re-treatment with vancomycin indicates its efficacy in managing recurrent CDI in children.

    • Implications:

    • Pediatricians should consider the possibility of C. diff relapse even after negative initial stool cultures.
    • Further research into the long-term management and prevention of recurrent CDI in children is warranted.
    • This case contributes to the understanding of C. diff infection dynamics in pediatric populations.