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Next-Generation Probiotics and Chronic Diseases: A Review of Current Research and Future Directions

Ashutosh Tiwari1, Dyah Ika Krisnawati2, Erna Susilowati3

  • 1International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.

Journal of Agricultural and Food Chemistry
|November 26, 2024
PubMed

Insights

Next-generation probiotics (NGPs), engineered microbes, offer targeted health benefits beyond traditional probiotics. Research explores their stability, delivery, and potential for treating chronic diseases like diabetes and obesity.

Area of Science:

  • Microbiome research
  • Synthetic biology
  • Therapeutic interventions

Background:

  • Traditional probiotics offer benefits, but their efficacy and mechanisms are unclear.
  • Fecal microbiota transplantation (FMT) shows promise, but long-term effects require further study.
  • High-throughput sequencing identifies beneficial gut microbes, leading to next-generation probiotics (NGPs).

Purpose of the Study:

  • To review current research on NGP stability, delivery challenges, and applications.
  • To explore NGP physiological characteristics, safety, and mechanisms of action.
  • To discuss challenges and opportunities for integrating NGPs into clinical practice.

Main Methods:

  • Literature review of current research on next-generation probiotics.
  • Analysis of NGP engineering through synthetic biology and bioinformatics.
  • Exploration of NGP applications in chronic disease prevention and treatment.

Main Results:

  • NGPs are engineered for enhanced stability and viability to target specific diseases.
  • Review covers NGP applications in diabetes, obesity, and cardiovascular diseases.
  • Physiological characteristics, safety profiles, and mechanisms of action are examined.

Conclusions:

  • NGPs hold immense potential to revolutionize microbiome-based therapies.
  • Further research is crucial to optimize NGP efficacy and ensure safety for clinical use.
  • NGPs may significantly improve clinical outcomes for various chronic conditions.
Keywords:
Chronic DiseasesHydrocolloidsMicrobiome-Based TherapiesNext-Generation ProbioticsSynthetic Biology

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