Related Experiment Video
Updated: Jun 6, 2025
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
27.8K
Insomnia and intestinal microbiota: a narrative review
Lu Liu1, Ji-Wei Zhu1, Jing-Lin Wu1
1Department of Respiratory and Critical Care Medicine, Binzhou Medical University Hospital, Binzhou Medical University, Binzhou, Shandong, 256603, China.
Sleep & Breathing = Schlaf & Atmung
|November 26, 2024
Summary
Insomnia disrupts the gut microbiota, impacting the microbiota-gut-brain axis. Interventions targeting gut microbiota show promise for treating insomnia by restoring microbial balance and improving sleep.
Area of Science:
- Microbiome research
- Neuroscience
- Sleep science
Background:
- The gut microbiota and insomnia are interconnected via the microbiota-gut-brain axis.
- Understanding this relationship is crucial for developing novel therapeutic strategies.
Purpose of the Study:
- To review changes in intestinal microbiota associated with insomnia.
- To analyze the interaction mechanisms between gut microbiota and insomnia.
- To evaluate microbiota-based treatments for insomnia.
Main Methods:
- Systematic literature search of PubMed and Embase databases up to March 2024.
- Inclusion of studies on gut microbiota in insomnia patients, interaction mechanisms, and treatment strategies.
Main Results:
- Insomnia can lead to gut microbiota dysbiosis through immune, neuroendocrine, and metabolic pathways, causing gut barrier dysfunction.
- Gut microbiota influences the central nervous system, potentially worsening insomnia symptoms.
- Interventions like probiotics, TCM, FMT, diet, and exercise aim to improve sleep by modulating neurotransmitters and microbial metabolites.
Conclusions:
- A significant interaction exists between insomnia and gut microbiota.
- Modulating gut microbiota presents a feasible approach for diagnosing and treating insomnia.
- Further large-scale studies, including fecal microbiota transplantation trials, are needed to confirm safety and efficacy.
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