Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Implicit Memories01:24

Implicit Memories

100
Implicit memories, also known as non-declarative memories, are long-term memories that function outside of conscious awareness. These memories influence behavior and skills without explicit knowledge. This type of memory is evident in tasks like playing tennis, snowboarding, and texting. Implicit memory has three subsystems: procedural memory, conditioning, and priming. This type of memory is essential in various activities, from everyday tasks to specialized skills.
One key aspect of implicit...
100
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

162
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
162

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antidepressant ketamine via oral gavage impairs fear memory, suppresses 22 kHz ultrasonic vocalizations, lowers GluN2A/B expression, and reduces medial habenula activity in rats.

Neuropharmacology·2025
Same author

Estrogen receptor alpha (ERα) partially modulates ketamine's sustained anxiolytic effects without altering its antidepressant properties in female rats.

Psychoneuroendocrinology·2025
Same author

Of rats and robots: A mutual learning paradigm.

Journal of the experimental analysis of behavior·2025
Same author

Basal forebrain innervation of the amygdala: an anatomical and computational exploration.

Brain structure & function·2025
Same author

The role of mGluR5 on the therapeutic effects of ketamine in Wistar rats.

Psychopharmacology·2024
Same author

Rodent tests of depression and anxiety: Construct validity and translational relevance.

Cognitive, affective & behavioral neuroscience·2024

Related Experiment Video

Updated: Jun 6, 2025

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

12.5K

Ketamine differentially affects implicit and explicit memory processes in rats.

Bahar Yuksel1, Zeynep Sen1, Gunes Unal2

  • 1Behavioral Neuroscience Laboratory, Department of Psychology, Boğaziçi University, Istanbul, 34342, Turkey.

Psychopharmacology
|November 26, 2024
PubMed
Summary

Ketamine, at antidepressant doses, does not impair fear or spatial memory recall. However, it disrupts fear extinction and aids reversal learning in spatial memory tasks.

Keywords:
Explicit memoryFear conditioningImplicit memoryKetamineMorris water maze

More Related Videos

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

8.3K
Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
07:52

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

11.9K

Related Experiment Videos

Last Updated: Jun 6, 2025

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

12.5K
Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
13:34

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

Published on: June 4, 2020

8.3K
Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
07:52

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

11.9K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Cognitive Psychology

Background:

  • Ketamine exhibits antidepressant properties via NMDA receptor antagonism.
  • Subanesthetic ketamine doses can cause cognitive deficits, including memory impairment.
  • The precise impact of ketamine on distinct memory processes requires further investigation.

Purpose of the Study:

  • To investigate the effects of an antidepressant ketamine dose (10 mg/kg) on fear and spatial memory.
  • To assess ketamine's influence on memory encoding, retrieval, and modulation.
  • To elucidate ketamine's differential effects on implicit (fear) and explicit (spatial) memory.

Main Methods:

  • Adult Wistar rats received ketamine (10 mg/kg) before fear conditioning (acquisition, retrieval, extinction) or Morris Water Maze (MWM) tasks (training, probe, reversal).
  • Pavlovian fear conditioning assessed cued fear memory.
  • MWM evaluated spatial learning and memory.

Main Results:

  • Ketamine administration before fear acquisition or retrieval partially hindered fear extinction.
  • Ketamine facilitated memory modulation, evidenced by reduced escape latency during MWM reversal training.
  • Neither fear memory nor spatial memory encoding or retrieval was significantly affected by ketamine.

Conclusions:

  • Ketamine does not impede the acquisition or retrieval of cued fear or spatial memories.
  • Ketamine differentially modulates memory, impairing fear extinction while enhancing spatial reversal learning.
  • Findings highlight ketamine's complex effects on memory consolidation and plasticity.