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Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

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Circular RNAs as multifaceted molecular regulators of vital activity and potential biomarkers of aging

Anna-Maria D Zharova1, Alexey D Perenkov1, Maria V Vedunova1,2

  • 1Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.

Epigenomics
|November 26, 2024
PubMed

Insights

Circular RNAs (circRNAs) show potential as aging biomarkers due to their stability and age-related accumulation. These molecules may drive aging processes and offer therapeutic targets for age-associated diseases.

Area of Science:

  • Gerontology
  • Molecular Biology
  • Biochemistry

Background:

  • Aging is a major challenge for healthcare systems, necessitating reliable biomarkers for progression assessment.
  • Circular RNAs (circRNAs) are stable, age-accumulating molecules found in biological fluids, making them promising aging biomarkers.
  • Understanding circRNA biogenesis and function is crucial for aging research.

Purpose of the Study:

  • To review current knowledge on circRNA expression and function in aging.
  • To explore the role of circRNAs in aging hallmarks like genomic stability and metabolism.
  • To identify circRNAs as potential epigenetic biomarkers and therapeutic targets for age-related diseases.

Main Methods:

  • Systematic review of scientific databases for circRNA expression data in aging.
  • Analysis of circRNA biogenesis and regulatory mechanisms.
  • Focus on circRNAs involved in aging-related cellular processes.

Main Results:

  • CircRNAs accumulate with age and are differentially expressed across species, including humans.
  • Age-related circRNA accumulation and deregulation may drive aging processes.
  • Specific circRNAs (e.g., circFOXO3, circRNA100783, circPVT1) are linked to aging.

Conclusions:

  • CircRNAs represent a novel class of epigenetic biomarkers for aging.
  • CircRNAs may play a causative role in aging and associated diseases.
  • Targeting circRNAs could offer new therapeutic strategies for age-related conditions.
Keywords:
agingbiomarkerscircRNAelderly populationlifespanncRNAsplicing

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