Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher Correction: Interplay between cohesin and RNA polymerase II in regulating chromatin interactions and gene transcription.

Nature structural & molecular biology·2026
Same author

The PLK4 inhibitor RP-1664 demonstrates potent efficacy in neuroblastoma preclinical models through a dual mechanism of sensitivity.

Nature communications·2026
Same author

p21-senescent cells drive pancreatic islet dysfunction through targetable paracrine signaling in type 2 diabetes.

JCI insight·2026
Same author

Distinct senescent β-cell senotypes differentially drive islet aging and dysfunction.

bioRxiv : the preprint server for biology·2026
Same author

Comparison of [18F]flortaucipir and [18F]MK6240 for the detection of tau pathology in Alzheimer's disease (HEAD): a multicentre, prospective, cross-sectional, within-participant study.

Lancet (London, England)·2026
Same author

Modeling patient variants of <i>Cnot1</i> and <i>Cdc42bpb</i> results in distinct forms of congenital diaphragmatic hernia in mice.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jun 23, 2026

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic &#8216;Touch DNA&#8217; Evidence
11:49

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence

Published on: March 9, 2015

15.6K

STRprofiler: efficient comparisons of short tandem repeat profiles for biomedical model authentication.

Jared M Andrews1, Michael W Lloyd2, Steven B Neuhauser2

  • 1Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, United States.

Bioinformatics (Oxford, England)
|November 26, 2024
PubMed
Summary

STRprofiler is a new software tool for comparing short tandem repeat (STR) profiles, aiding in the authentication of biomedical models. It offers high-throughput comparison and cross-contamination detection against custom or existing databases like Cellosaurus.

More Related Videos

Genotyping of Staphylococcus aureus by Ribosomal Spacer PCR RS-PCR
08:51

Genotyping of Staphylococcus aureus by Ribosomal Spacer PCR RS-PCR

Published on: November 4, 2016

9.6K
Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes
08:35

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes

Published on: July 17, 2021

20.0K

Related Experiment Videos

Last Updated: Jun 23, 2026

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic &#8216;Touch DNA&#8217; Evidence
11:49

Enhanced Genetic Analysis of Single Human Bioparticles Recovered by Simplified Micromanipulation from Forensic ‘Touch DNA’ Evidence

Published on: March 9, 2015

15.6K
Genotyping of Staphylococcus aureus by Ribosomal Spacer PCR RS-PCR
08:51

Genotyping of Staphylococcus aureus by Ribosomal Spacer PCR RS-PCR

Published on: November 4, 2016

9.6K
Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes
08:35

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes

Published on: July 17, 2021

20.0K

Area of Science:

  • Biotechnology
  • Bioinformatics
  • Genomics

Background:

  • Short tandem repeat (STR) profiling is crucial for authenticating human-derived biomedical models.
  • Existing methods lack high-throughput capabilities for comparing multiple STR profiles or querying databases.

Purpose of the Study:

  • To introduce STRprofiler, a versatile software package for STR profile analysis.
  • To enable efficient comparison of STR profiles and detection of cross-contamination.
  • To facilitate authentication of biomedical models using STR data.

Main Methods:

  • Development of STRprofiler as a Python package, command-line tool, and Shiny application.
  • Implementation of algorithms for high-throughput STR profile comparison.
  • Integration with custom databases and the Cellosaurus cell line database.

Main Results:

  • STRprofiler provides a user-friendly interface for STR profile analysis.
  • The tool enables rapid comparison of STR profiles and identification of potential cross-contamination.
  • STRprofiler supports querying against various databases, enhancing model authentication.

Conclusions:

  • STRprofiler addresses the need for efficient STR profile comparison and cross-contamination detection.
  • This tool will improve the reliability and accuracy of biomedical model authentication.
  • STRprofiler is freely available, promoting its widespread adoption in research.