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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Non-Canonical Wnt Signaling Pathways01:41

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

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Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
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Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

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Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
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Related Experiment Video

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Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Structural and Functional Insights into Dishevelled-Mediated Wnt Signaling.

Lei Wang1, Rui Zhu1, Zehua Wen1

  • 1College of Chemical Engineering, Sichuan University of Science and Engineering, Zigong 643000, China.

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|November 27, 2024
PubMed
Summary

Dishevelled (DVL) proteins are key regulators of Wnt signaling. This study explores DVL

Keywords:
AlphaFoldDishevelledWntcancermechanismpost-translation

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Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Structural Biology

Background:

  • Dishevelled (DVL) proteins are crucial regulators of Wnt signaling pathways, influencing numerous downstream effectors.
  • Despite extensive research, the precise regulatory mechanisms and interaction networks of DVL proteins remain incompletely understood.

Purpose of the Study:

  • To present recent advances and future perspectives on how Dishevelled (DVL) proteins regulate Wnt signaling.
  • To elucidate the structural basis of DVL's function in Wnt pathway regulation using integrated experimental and computational approaches.
  • To summarize the involvement of DVL in various diseases and identify potential therapeutic avenues.

Main Methods:

  • Integration of experimentally determined conserved domain structures of DVL proteins.
  • Utilization of AlphaFold-predicted structures to model DVL interactions and functions.
  • Comprehensive review of existing literature on DVL's role in disease pathogenesis.

Main Results:

  • Structural insights into DVL proteins provide a framework for understanding their regulatory roles in Wnt signaling.
  • The study highlights the multifaceted involvement of DVL in diverse disease contexts.
  • Identification of key areas for future research into DVL-mediated signaling mechanisms.

Conclusions:

  • Dishevelled (DVL) proteins play a critical role in Wnt signaling, with significant implications for human health.
  • Understanding DVL structure-function relationships is essential for deciphering its regulatory activities.
  • DVL represents a promising therapeutic target and biomarker for various diseases, warranting further investigation for biomedical applications.