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A Cross-Sectional Study: Systematic Quantification of Chemerin in Human Cerebrospinal Fluid
Alexandra Höpfinger1, Manuel Behrendt1, Andreas Schmid1
1Department of Internal Medicine III, University of Giessen, Klinikstr. 33, 35392 Giessen, Germany.
Biomedicines
|November 27, 2024
Summary
Chemerin is present in cerebrospinal fluid and crosses the blood/CSF barrier. Its levels are influenced by body mass index (BMI), sex, and neurological conditions.
Area of Science:
- Neuroscience
- Endocrinology
- Immunology
Background:
- Adipokine dysregulation is central to metabolic syndrome and chronic inflammation.
- Chemerin, an adipokine, is linked to metabolic syndrome, cardiovascular disease, and immune responses.
- Limited data exists on chemerin's presence in cerebrospinal fluid (CSF) and its blood-brain barrier (BBB) permeability.
Purpose of the Study:
- To quantify chemerin levels in paired serum and CSF samples.
- To investigate the relationship between serum and CSF chemerin levels and various clinical parameters.
- To determine if chemerin can cross the blood/CSF barrier.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure chemerin in 390 patients' serum and CSF.
- Correlation analyses were performed between chemerin levels and anthropometric, serum, and CSF parameters.
- The CSF/serum chemerin ratio was calculated.
Main Results:
- Overweight individuals had higher serum and CSF chemerin levels.
- CSF chemerin levels were elevated in men and associated with age.
- Serum chemerin correlated with BMI and C-reactive protein (CRP); CSF chemerin was affected by neurological diseases.
Conclusions:
- Chemerin is quantifiable in CSF and crosses the blood/CSF barrier.
- CSF chemerin levels are influenced by BMI, sex, and neurological status.
- This study provides a foundation for establishing normal CSF chemerin reference values.
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