Hyaluronic Acid Combined with Ozone in Dental Practice

Area of Science:

• Periodontal medicine
• Regenerative dentistry
• Oral therapeutics

Background:

• Topical drug delivery targets soft and hard oral tissues.
• Hyaluronic acid (HA) and ozone therapy are increasingly used for inflammation and post-dental procedure healing.

Purpose of the Study:

• To systematically review the efficacy of topical HA in managing acute and chronic inflammatory oral conditions.
• To assess HA's role in healing after dental surgeries.

Main Methods:

• Systematic literature search of PubMed, Google Scholar, and Ovid (June 2015–May 2024).
• Study registered under Prospero CRD42024569641.
• Included 28 studies on gingivitis, periodontitis, dental surgeries, and oral ulcers.

Main Results:

• Risk of bias assessed using RoB 2 tool.
• 75% of studies had high risk of bias in randomization; 100% had low risk in allocation concealment.
• 85% of studies showed low risk of reporting bias.

Conclusions:

• Topical HA combined with ozone therapy is highly effective for post-operative dental healing.
• This combination yields positive outcomes for chronic gingivitis, periodontal inflammation, and oral ulcers.