Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

2.4K
Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
2.4K
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

3.0K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
3.0K
Fibril-associated Collagen01:11

Fibril-associated Collagen

2.5K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
2.5K
Fibrous Proteins00:55

Fibrous Proteins

2.0K
Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...
2.0K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.6K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.6K
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

4.1K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Boltzmann-Loschmidt Dispute Reloaded: Quantum 150 Years Later.

Entropy (Basel, Switzerland)·2026
Same author

Transcriptome fingerprinting of aberrant fibroblast activation unlocks effective therapeutics to tackle cardiac fibrosis.

Science advances·2025
Same author

Targeting fibroblast phenotype switching in cardiac remodelling as a promising antifibrotic strategy.

European heart journal·2024
Same author

Quantum Synchronization and Entanglement of Dissipative Qubits Coupled to a Resonator.

Entropy (Basel, Switzerland)·2024
Same author

Opinion Formation in the World Trade Network.

Entropy (Basel, Switzerland)·2024
Same author

Dollar-Yuan Battle in the World Trade Network.

Entropy (Basel, Switzerland)·2023
Same journal

Correction: Reis et al. Bioinks Enriched with ECM Components Obtained by Supercritical Extraction. <i>Biomolecules</i> 2022, <i>12</i>, 394.

Biomolecules·2026
Same journal

Correction: Kim, K.-H.; Yoo, B.C. Gintonin as a Lysophosphatidic Acid-Enriched GPCR Ligand System: Molecular Architecture and Receptor Pharmacology in <i>Panax ginseng</i>. <i>Biomolecules</i> 2026, <i>16</i>, 465.

Biomolecules·2026
Same journal

Correction: Bastyte et al. The Association of Vitamin D Receptor Gene Polymorphisms with Vitamin D, Total IgE, and Blood Eosinophils in Patients with Atopy. <i>Biomolecules</i> 2024, <i>14</i>, 212.

Biomolecules·2026
Same journal

AtHSPR Plays a Positive Role in Arabidopsis Resistance Against <i>Pseudomonas syringae</i> pv. <i>tomato</i> DC3000 by Interacting with TOP1.

Biomolecules·2026
Same journal

CYTH4 Facilitates Renal Cell Carcinoma via Enhancing Proliferation and Likely Immune Evasion.

Biomolecules·2026
Same journal

Integrated Immune-Gut Profiling Identifies an Exploratory Pediatric Inflammatory Intestinal Profile Associated with Food-Specific IgG Reactivity.

Biomolecules·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.0K

Fibroblast-Specific Protein-Protein Interactions for Myocardial Fibrosis from MetaCore Network.

Klaus M Frahm1, Ekaterina Kotelnikova2, Oksana Kunduzova3,4

  • 1Laboratoire de Physique Théorique, Université de Toulouse, CNRS, UPS, 31062 Toulouse, France.

Biomolecules
|November 27, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces a novel network model to understand cardiac fibrosis, a key factor in cardiovascular diseases. The model identifies potential targets to reverse fibrosis progression and aid therapeutic development.

Keywords:
Ising spinMarkov chainsMonte Carlo methoddirected networksfibrosisopinion formationprotein-protein interactions

More Related Videos

Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts
10:45

Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts

Published on: March 12, 2020

15.8K
Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

7.2K

Related Experiment Videos

Last Updated: Jun 6, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.0K
Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts
10:45

Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts

Published on: March 12, 2020

15.8K
Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

7.2K

Area of Science:

  • Cardiovascular Biology
  • Systems Biology
  • Computational Biology

Background:

  • Myocardial fibrosis is a pathological hallmark of numerous cardiovascular diseases (CVD).
  • Its complex pathogenesis involves multiple molecular pathways.
  • Understanding protein-protein interactions (PPI) is crucial for identifying therapeutic targets.

Purpose of the Study:

  • To construct a fibrosis-focused protein-protein interaction (PPI) network.
  • To identify key fibroblast-specific arbitrators in myocardial fibrosis.
  • To predict regulatory mechanisms and therapeutic strategies for cardiac fibrosis.

Main Methods:

  • Integration of fibrosis-associated genes into a global protein-protein interaction (PPI) network.
  • Development of a network analysis approach to predict regulatory mechanisms.
  • Application of an Erdös barrage method to identify suppressible fibrosis-associated nodes.
  • Modeling fibrosis progression using an Ising Network Fibrosis Interaction model with Monte Carlo simulations.

Main Results:

  • Generation of a novel fibrosis-focused PPI network.
  • Identification of fibroblast-specific arbitrators driving myocardial fibrosis.
  • Prediction of new regulatory mechanisms in TGF-β-mediated fibroblast activation.
  • Demonstration of an approach to suppress fibrotic cascades using network analysis.

Conclusions:

  • The developed Ising Network Fibrosis Interaction model provides network-based insights into cardiac fibrosis mechanisms.
  • This model can guide future experimental efforts to counteract myocardial fibrosis.
  • The study highlights potential therapeutic targets for cardiovascular diseases associated with fibrosis.