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Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants-Single-Center Study
Justyna Jachman-Kapułka1, Aleksander Zińczuk2, Krzysztof Simon2,3
16th Department of Internal Medicine, J. Gromkowski Specialist Regional Hospital, 51-149 Wroclaw, Poland.
Brain Sciences
|November 27, 2024
Summary
Neurological symptoms like delirium and stroke increased in frequency during the Omicron variant
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- The Omicron variant of SARS-CoV-2 is known for continuous mutation.
- New strains exhibit varying neuropathogenicity and neurological disease spectrums.
Purpose of the Study:
- To assess the frequency and clinical characteristics of neurological manifestations in hospitalized patients during Omicron dominance.
- To compare these manifestations across three distinct Omicron subvariant periods.
Main Methods:
- A retrospective, single-center study of 426 hospitalized COVID-19 patients.
- Patients were divided into three periods based on Omicron subvariant dominance in Poland.
- Demographic and clinical data, focusing on neurological manifestations, were collected and analyzed.
Main Results:
- Neurological manifestations occurred in 55.4% of patients, with delirium, headache, myalgia, dizziness, cerebrovascular diseases, and encephalopathy being most common.
- Subsequent Omicron periods showed increased frequencies of delirium, transient ischemic attack (TIA), and encephalopathy.
- Headache and myalgia correlated with shorter hospital stays, while delirium, cerebrovascular diseases, and ischemic stroke were linked to higher mortality risk.
Conclusions:
- The Omicron variant causes a broad range of neurological issues.
- Despite improved COVID-19 survival rates, the incidence of neurological manifestations is rising.
- Delirium, cerebrovascular diseases, and ischemic stroke significantly increase mortality risk.
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