Related Experiment Video

Updated: Jun 6, 2025

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
08:28

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods

Published on: March 10, 2020

6.8K

Genetic Insights into Congenital Cardiac Septal Defects-A Narrative Review

Jorge L Cervantes-Salazar1, Nonanzit Pérez-Hernández2, Juan Calderón-Colmenero3

  • 1Department of Pediatric Cardiac Surgery and Congenital Heart Disease, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.

Biology
|November 27, 2024
PubMed

Insights

Congenital heart diseases (CHDs), including common septal defects like ventricular (VSD) and atrial septal defects (ASD), arise from genetic and environmental factors. This review covers genetics in heart development and treatments for these conditions.

Area of Science:

  • Cardiology
  • Developmental Biology
  • Genetics

Background:

  • Congenital heart diseases (CHDs) are prevalent, complex conditions affecting heart development.
  • Septal defects, specifically ventricular septal defects (VSD) and atrial septal defects (ASD), are the most common CHDs.
  • CHDs result from intricate interactions between genetic and environmental influences.

Purpose of the Study:

  • To review and summarize the genetic factors influencing cardiogenesis.
  • To elucidate the genetic basis of congenital cardiac septal defects (VSDs and ASDs).
  • To address current and emerging treatment strategies for these conditions.

Main Methods:

  • Comprehensive literature review of genetic and developmental studies.
  • Analysis of research on the etiology of congenital heart defects.
  • Synthesis of information on therapeutic interventions for septal defects.

Main Results:

  • Genetics plays a critical role in normal heart formation and the development of septal defects.
  • Identified key genes and pathways implicated in cardiogenesis and CHD pathogenesis.
  • Outlined various treatment modalities, from surgical repair to potential future therapies.

Conclusions:

  • Understanding the genetic underpinnings of CHDs is crucial for diagnosis and treatment.
  • Genetic and environmental factors interact to cause septal defects.
  • Continued research into genetics and treatment is vital for improving outcomes in congenital heart disease.

Keywords:
cardiogenesiscongenital heart diseasegeneticsseptal defects

More Related Videos

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

11.5K
A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse08:19

A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse

Published on: December 16, 2022

1.8K

Related Concept Videos

Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
2
Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
875