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Genetic Insights into Peripheral Artery Disease: A Narrative Review
Nonanzit Pérez-Hernández1, José Manuel Rodríguez-Pérez1, Luis Eduardo Nicanor-Juárez1,2
1Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Biomedicines
|November 27, 2025
Summary
Genetic and environmental factors contribute to peripheral arterial disease (PAD). This review details genetic variants, pathways, and gene expression linked to PAD, aiding in developing better patient interventions.
Area of Science:
- Genetics and Molecular Biology
- Cardiovascular Disease Research
- Pathophysiology
Background:
- Peripheral arterial disease (PAD) is a widespread atherosclerotic condition affecting lower extremity arteries.
- PAD involves complex genetic and environmental factors influencing its development and progression.
- Reduced blood flow in the extremities is a hallmark of PAD.
Purpose of the Study:
- To review key genetic variants associated with PAD plaque initiation, progression, and rupture.
- To identify relevant KEGG pathways implicated in PAD pathogenesis.
- To summarize gene expression and transcriptomic findings in PAD patient biopsies.
Main Methods:
- Literature review of genetic association studies in PAD.
- Analysis of KEGG pathway databases for relevant biological processes.
- Examination of transcriptomic data from PAD patient samples.
Main Results:
- Identification of specific genetic variants contributing to PAD.
- Association of certain KEGG pathways with PAD pathophysiology.
- Insights from gene expression studies on PAD mechanisms.
Conclusions:
- Understanding genetic factors is crucial for elucidating PAD.
- KEGG pathway analysis provides a framework for PAD molecular mechanisms.
- Transcriptomic data offers functional insights into PAD phenotypes, guiding therapeutic development.
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